1.题目：A novel peroral choledochoscope was used to remove a proximal displaced stent-ston
e complex.
作者：Li, Yaoting; Yu, Tingting; He, Hongfei; ...... Zhang, Lichao;
通讯作者：通讯作者：张立超 科室：普外九科
期刊：ENDOSCOPY. 2023-12-01;55(S 01):E608-E610.
文献类型：Editorial Material
影响因子：9.3 (2022) 中科院分区：1区
PMID：37040885
WOS:000969077300004
2.题目：SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by
facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm.
作者：Yang, Zhan; Wang, Ya-Xuan; Wen, Jin-Kun; ...... Qu, Chang-Bao;
通讯作者：瞿长宝 科室：泌尿外科
期刊：Cell Death Dis. 2023-01-13;14(1):26.
影响因子：9 (2022); 中科院分区：2区
PMID：36639679
WOS: 000989313600005
摘要：Splicing factor 3B subunit 4 (SF3B4) plays important functional roles not only in pre-mR
NA splicing, but also in the regulation of transcription, translation, and cell signaling, and its d
ysregulation contributes to various diseases including Nager syndrome and tumorigenesis. Ho
wever, the role of SF3B4 and underlying mechanisms in clear cell renal cell carcinoma (ccRCC)
remain obscure. In the present study, we found that the expression of SF3B4 was significantly
elevated in ccRCC tissues and negatively correlated with the overall survival of ccRCC patients
. Upregulation of SF3B4 promotes migration and invasion of ccRCC cells in vitro and in vivo. T
he promoting effect of SF3B4 on cell migration and invasion is mediated by Twist1, a key tran
scription factor to mediate EMT. Interestingly, SF3B4, a component of the pre-mRNA spliceoso
me, is able to promote KLF16 expression by facilitating the transport of KLF16 mRNA into the
cytoplasm. Mechanistically, SF3B4 promotes the export of KLF16 mRNA from the nucleus to
the cytoplasm and thus enhances KLF16 expression, and in turn elevated KLF16 directly binds
to the Twist1 promoter to activate its transcription, leading to EMT and ccRCC progression.
Our findings provide evidence that the SF3B4-KLF16-Twist1 axis plays important functional ro
les in the development and progression of ccRCC, and manipulating this pathway may be a no
vel therapeutic target for the treatment of ccRCC.
3.标题：Association of exposure to perfluoroalkyl substances and risk of the; acute coronary sy
ndrome: A case-control study in Shijiazhuang Hebei; Province
作者：Li, Haoran#; Chen, Jinbo; Lu, Jingchao; Yang, Jing; Tan, Zhenzhen; Li, Longfei; Xiao, Fang;
An, Ziwen; Ma, Chaoying; Liu, Yi; Wang, Lei; Zhang, Xiaoguang; Guo, Huicai*;
第一作者：李浩然 科室：药学部
期刊：CHEMOSPHERE 2023FEB;313卷
文献类型：Article
影响因子: 8.8(2022)；中科院分区：2区
PMID: 36495974
WOS: 000904121100004
摘要：Exposures to perfluoroalkyl substances (PFAS) have been reported to increase the risk
of atherosclerosis. Therefore, PFAS exposure may be linked to the risk of acute coronary syndr
ome (ACS), but this association remains uncertain. The objective of the present study was to in
vestigate the association between PFAS exposure and ACS risk through a case-control study.
The study included 355 newly diagnosed ACS cases and 355 controls matched by age (within
5 years) and sex. Twelve PFAS were measured in plasma by ultra-high-performance liquid chr
omatography-tandem mass spectrometry. The conditional logistic regression models were per
formed to investigate the association between the single and multiple PFAS and ACS risk. Furt
hermore, we investigated the association of PFAS mixture exposure with ACS risk using a quan
tile-based g-computation (qgcomp) approach. A mediating effect model was used to assess
the mediating effect of platelet indices on the association between PFAS and ACS risk. The res
ults showed that perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) were
significantly positively associated with ACS risk in the multiple-PFAS model 2, and this effect
was not significant in females. The odds ratios (95% confidence intervals) for PFAS (z-score PF
AS) and ACS risk were 1.51 (1.07, 2.15) for PFOA and 1.77 (1.15, 2.72) for PFOS. The dose-resp
onse relationships revealed an increasing trend for ACS risk with PFOA and PFOS and decreasi
ng trend for perfluorohexane sulfonic acid (PFHxS) and perfluorodecanoic acid (PFDA). There
was no significant correlation between PFAS mixture exposure and ACS risk. Analysis of media
tion indicated that platelet count mediated the relationship between PFOS and ACS risk. Our
study suggests that higher levels of PFOA and PFOS, and lower levels of PFHxS and PFDA may
increase the risk of ACS. However, the reported negative associations should not be considere
d as protective, and uncertain unresolved confounding may contribute to this result.
4.标题：N-doped core-shell mesoporous carbon spheres embedded by Ni nanoparticles for
CO2 electroreduction
作者：Du, Juan#; Lin, Qin-Yan; Zhang, Jian-Qi; Hou, Sen-Lin*; Chen, Ai-Bing*;
共同通讯作者：侯森林 科室：普外九科
期刊：RARE METALS 2023 MAY 20
文献类型：Article
影响因子: 8.8(2022) 中科院分区：1区
WOS:000992707400001